Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Intra-operative 3D ultrasound augmentation

We introduce an automated and accurate system for registering pre-operative 3D MR and CT images with intraoperative 3D ultrasound images based on the vessels visible in both. The clinical goal is to guide the radio-frequency ablation (RFA) of liver lesions using percutaneous ultrasound even when the lesions are not directly visible using ultrasound. The lesions locations and desired RFA sites a...

A New Brain Drug Delivery Strategy: Focused Ultrasound-Enhanced Intranasal Drug Delivery

Central nervous system (CNS) diseases are difficult to treat because of the blood-brain barrier (BBB), which prevents most drugs from entering into the brain. Intranasal (i.n.) administration is a promising approach for drug delivery to the brain, bypassing the BBB; however, its application has been restricted to particularly potent substances and it does not offer localized delivery to specifi...

Mathematical Analysis of Drug Release for Gastrointestinal Targeted Delivery Using β-Lactoglobulin Nanoparticle

To answer challenge of targeted and controlled drug release in oral delivery various materials were studied by different methods. In the present paper, controlled metal based drug (Pd(II) complex) release manner of β‑Lactoglobulin (β-LG) nanoparticles was investigated using mathematical drug release model in order to design and production of a new oral drug delivery system for gastrointestinal ...

Enhancing drug delivery for boron neutron capture therapy of brain tumors with focused ultrasound.

BACKGROUND Glioblastoma is a notoriously difficult tumor to treat because of its relative sanctuary in the brain and infiltrative behavior. Therapies need to penetrate the CNS but avoid collateral tissue injury. Boron neutron capture therapy (BNCT) is a treatment whereby a (10)B-containing drug preferentially accumulates in malignant cells and causes highly localized damage when exposed to epit...

Ultrasound-mediated Drug Delivery